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JaK/STAT inhibition to prevent post-traumatic epilepsy

Posted 10/4/2013 12:10 AM by Nicole Garneau | Comments

Conversations in Local Health Research

Friday, December 13, 2013

10:30 to 11:30 a.m., Ricketson Auditorium

Brown Bag Lunch with speaker to follow presentation

JaK/STAT inhibition to prevent post-traumatic epilepsy

Daniel Raible


Traumatic brain injury (TBI) is damage to the brain resulting from external force.  Numerous studies have suggested that TBI significantly increases the chance of developing epilepsy and that the more severe the trauma the increased likelihood of developing epilepsy. This is a topical concern for parents with children in sports activities that increases the chance of TBI. Understanding the relationship between TBI and the development of epilepsy at the cellular level could lead to improved treatments for TBI patients and offer insights into the prevention of epilepsy after head trauma.

Join us as we learn about Dan’s research to examine the role of signaling, both in and between, cells after a TBI using two different severities of head trauma. His research shows that advanced helmets and head protections limit negative cellular signaling and improve neurological outcomes after a TBI.

Daniel Raible works at the Brooks-Kayal Lab in the Neuroscience Program at the University of Colorado School of Medicine. His advisor is Amy Brooks-Kayal.

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